Scientists have identified a rare genetic mutation that is responsible for inherited hives that are induced by vibration. Any movement that causes vibration, such as hand clapping, running or a bumpy car ride, will produce skin rashes in people with this disorder, which is also known as vibratory urticaria. Vibrations can trigger the release of inflammatory chemicals from the mast cells of the body’s immune system. These chemicals result in hives and other allergy symptoms.
Researchers who have studied vibratory urticaria found that people with the condition have higher levels of histamine and tryptase in their blood than those people without the allergy. When people with vibratory allergies experience a triggering motion, their mast cells start releasing these chemicals.
Scientists at the National Institutes of Health conducted genetic analyses of 36 individuals from three families with members who are both affected and unaffected by the allergy. The study included DNA sequencing. The scientists found a single mutation in the ADGRE2 gene in family members with vibratory urticaria. That gene mutation was not present in the family members who were not affected by the allergy.
To expand the study, scientists researched the DNA of more than 1,000 unaffected people with the same genetic ancestry as the three families in the study. These individuals did not have the ADGRE2 mutation.
The study provided a clear understanding of the underlying causes of vibratory urticaria. Individuals who suspect that they suffer from this condition should consult a Scottsdale allergy doctor for proper diagnosis and management.